Fatal acute liver failure with hepatitis B virus infection during nataluzimab treatment in multiple sclerosis

A 28-year-old woman with multiple sclerosis (MS) presented to the emergency department (ED) at University Hospital in Newark, NJ on March 10, 2011 with epigastric abdominal pain, a low-grade fever, chills, shortness of breath, pleuritic pain, and impaired balance of 2 days’ duration. She also reported right arm numbness and dizziness, consistent with her previous symptoms of MS. She had 3 episodes of nonbloody, nonbilious vomiting while in the ED. The patient had had a root canal procedure 2 weeks earlier. The patient was diagnosed with aggressive relapsing-remitting MS in February 2003. Her past MS exacerbations numbered more than 10, and she had been treated previously with interferon b-1b, glatiramer acetate, cladribine, prednisone, and cyclophosphamide. She started monthly natalizumab (NTZ) infusions in May 2009 and tolerated the drug without any side effects until March 2011. She received a total of 22 monthly infusions. Her most recent visit, for a lab draw, occurred 3 days prior to presentation, and her lab test that day, arranged post hoc, demonstrated positive immunoglobulin M (IgM) anti–hepatitis B core antibody (anti-HBc) and negative anti–hepatitis B surface antibody (anti-HBs). The patient did not smoke, use alcohol, or take IV drugs. She was sexually active with one partner. She had never been vaccinated with hepatitis B. Hepatitis B viral markers in 2006 were negative for hepatitis B surface antigen (HBsAg), IgM anti-HBc, and anti-HBs. On examination, her blood pressure was 107/68 mm Hg, pulse was 108 bpm, respiratory rate was 18, and temperature was 99.6°F. She was awake, alert, and oriented to time, place, and person. Her pupils were equal, round, and reactive. Strength was 4/5 in both upper extremities and 5/5 in both lower extremities. Sensation to light touch, deep touch, and pinprick was diminished in the right arm and hand. Reflexes were brisk throughout and plantar responses were flexor. Fine finger movements were slow. There was no dysmetria on finger-to-nose or heel-to-shin testing. She had an unsteady gait. Initial workup showed a leukocyte count of 5,400/uL, hemoglobin of 12.5 g/dL, and platelet count of 123,000. Liver function tests were as follows: aspartate aminotransferase (AST): 1,203 U/L; alanine aminotransferase (ALT): 1,564 U/L; total bilirubin: 1.0 mg/dL; alkaline phosphatase: 70 U/L. International normalized ratio (INR) was 1.2 (table). On the night of her admission, she spiked a temperature of 103°F. Blood and urine cultures were negative. She was started empirically on vancomycin and piperacillin/tazobactam. Subsequent complete blood count with differential demonstrated neutropenia. Steroids were not administered. On March 12, her AST rose to 10,730 U/L, ALT was 7,226 U/L, alkaline phosphatase was 120 U/L, total bilirubin was 4.2 mg/dL, and INR was 3.4. Viral hepatitis markers (March 11) were as follows: HBsAg, anti-HBs, and IgM anti-HBc were positive, while hepatitis C antibody and anti–hepatitis A virus IgM were negative. She had 7,973,400 copies/mL of hepatitis B virus (HBV) DNA. She was transferred to the hepatology service and started on entecavir, N-acetylcysteine, lactulose, and vitamin K. Her transaminase levels continued to worsen. On March 13th, she developed hepatic encephalopathy with behavioral changes. Treatment with liver transplant was entertained, but the patient and her family refused. She died on March 14, 2011.